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Determine Optimal Dosing and Administration: Establish standardized and evidence-based dosing protocols, frequencies, and routes of administration for various indications
Chronic, uninterrupted activation can lead to pathway desensitization, the biological equivalent of diminishing returns
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9 During AOM-induced HE, the upregulation of MMP9 has been shown to disrupt tight junction expression, and pharmacological inhibition of MMP9 restores tight junction protein expression to near control levels
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Phase II: Maintenance and Consolidation (Weeks 5 8) This phase transitions to a lower TB-500 maintenance dose to sustain the systemic environment while continuing the local BPC-157 signal
